Some NOXs regulate specific redox-signaling pathways in cells through secreting ROS to the plasma membrane, endosomes, focal adhesion, or other cellular compartments, and then activate or suppress local oncoproteins or tumor suppressors.8,39 Our data show that the formation of Pyk2/NOX5/c-Abl complex facilitates redox-sensitive activation of Src at focal complex. This evidence concerns the gene PTK2B and neoplasm.