VDAC1 and acute myeloid leukemia: Finally, to test the functional relevance of the role of autophagy-dependent MERCs formation, we monitored the proliferation of VDAC1-depleted cells in vitro and in vivo, or we daily treated NOD-SCID-gamma (NSG) immunodeficient mice engrafted with AML MOLM14 cells, with an oral potent ETC complex I inhibitor, the IACS-01075940.