This approach revealed that both basal OCR and mitochondrial ATP production-linked OCR were significantly decreased, when autophagy was inhibited either with 3-MA (Fig. 1j, Supplementary Fig. 1m, n) or with a small interfering RNA (siRNA) targeting Beclin1 in AML cells (Fig. 1k, Supplementary Fig. 1o, p). The gene discussed is BECN1; the disease is acute myeloid leukemia.