The verified tumor promotion genes included in (a)-(1) type such as PKM, Tpd52, Tpm4, Ly6d, Hk2, Nqo1, Phgdh, Rab3d, Alcam, Aldh3a1, Asns, Hspa5, Hsp90b1, Txndc5, and Prkar2b and the tumor suppressor genes included in(c)-(1) type such as Rgn, Maob, Sirt3, Pbld, Pck1, Lhpp, Gnmt, Gls2, Hadh, Decr1, Hmgcs2, Fbp1, Dmgdh, Hint2, and Sdhb further confirmed the authenticity of classification analysis of the proteomic data from Ras-Tg (Additional file 6, Table S5). This evidence concerns the gene SIRT3 and neoplasm.