The verified tumor promotion genes included in (a)-(1) type such as PKM, Tpd52, Tpm4, Ly6d, Hk2, Nqo1, Phgdh, Rab3d, Alcam, Aldh3a1, Asns, Hspa5, Hsp90b1, Txndc5, and Prkar2b and the tumor suppressor genes included in(c)-(1) type such as Rgn, Maob, Sirt3, Pbld, Pck1, Lhpp, Gnmt, Gls2, Hadh, Decr1, Hmgcs2, Fbp1, Dmgdh, Hint2, and Sdhb further confirmed the authenticity of classification analysis of the proteomic data from Ras-Tg (Additional file 6, Table S5). The gene discussed is HADH; the disease is neoplasm.