This mechanism of downregulation of CDKN1A in human prostate (RWPE, PNT1A, and PC3) cell lines is reminiscent of the downregulation induced by ETV4 through binding to other promoters, such as that of ERBB2 promoter in breast and ovarian cancer cells [62, 66] and that of collagenase-1 promoter in a breast cell line treated with all-trans retinoic acid [67]. This evidence concerns the gene CDKN1A and ovarian carcinoma.