In addition, Aytes and colleagues have reported the late increase of ETV4 expression in a prostate metastasis mouse model with several genetic alterations (pTen loss, NKX3.1 deletion, and a KRAS activating mutation) suggesting that ETV4 may have a role in the metastatic process even in prostate cancers that do not overexpress ETV4 initially [71]. This evidence concerns the gene NKX3-1 and Familial prostate cancer.