MMP9 and alkaline phosphatase measurement: In ETV4 mice (n = 7), we found no variations of MMPs expression in AP; however, we found increased expression of MMP2, MMP7, and MMP9 mRNA in VP (3.0 ± 0.7, 3.7 ± 0.7, and 2.5 ± 0.7 fold respectively; P < 0.05) and in DLP (8.6 ± 3.5; 4.7 ± 1.8, and 1.8 ± 0.3 folds respectively; P < 0.08 not significant), suggesting that ETV4 regulates MMPs expression also in vivo.