ARID1A and cancer: In this research, we confirmed the important role of ARID1A deficiency in elevating cancerous mutability and changing tumors to exhibit an aggressive phenotype in NSCLC, which was proposed by published works (Shen et al. 2018; Jiang et al. 2020; Okamura et al. 2020; Rossi et al. 2020) on other cancer types.