CD274 and neoplasm: During trials evaluating ICIs, several biomarkers have been found to be related to sensitivity to ICIs treatment, including high programmed death-ligand 1 (PD-L1) expression (Mok et al. 2019; Ready et al. 2019; Ott et al. 2019), a high tumor mutational burden (TMB) (Ready et al. 2019; Ott et al. 2019) and mismatch repair (MMR) deficiency (Mandal et al. 2019).