A recent study showed that LLLT significantly inhibited total IgE and IL-4 and improved histological damage to the epithelium in the nasal septum of ovalbumin-induced mice.[26] Previous studies demonstrated that LLLT is an effective modality for treating AR, as it significantly alleviated rhinitis symptoms and improved QOL; additionally, these studies reported no serious side effects or complications.[23,27,28] However, there are still limitations with the current research, including the differences in study design, laser power density, dosage, and wavelength. The gene discussed is IL4; the disease is rhinitis.