In addition, heart failure is also an independent risk factor for T2DM.[7] After heart failure occurs, the body activates the sympathetic nervous system and the renin-angiotensin-aldosterone system through the mechanism of neurohumoral regulation, which aggravates insulin resistance and increases blood glucose; increased catecholamine concentration in myocardial tissue causes cardiomyocyte apoptosis; blood vessels. This evidence concerns the gene REN and heart failure.