Whereas authors who performed IHC analysis of OSCCHT have postulated a germ cell-derived tumor, other authors have discussed OSCCHT as an epithelial-like originating tumor, and genetic analysis of OSCCHT tumor specimens have identified an inhomogeneous tumor entity.[14] As mentioned above, accumulating evidence has shown that SMARCA4 is mutated in 75% to 100% of OSCCHT cases,[11,13] which is a similar genetic profile to malignant rhabdoid tumors. This evidence concerns the gene SMARCA4 and neoplasm.