Nevertheless, recent work shows that the ortholog of GOLPH3 from Drosophila melanogaster interacts with the corresponding orthologs of RAB1, RAB5 and RAB11 [22, 23], and that GOLPH3 from the human glioma cell line U87 associates to RAB5 in a protein complex that also contains the epidermal growth factor receptor [24]. Here, RAB5A is linked to central nervous system cancer.