Fig 3A shows the morphological and confluency changes after treatment with SB203580 and IL-6 in both PLum-AD and PLum-AI, compared to the control in each. Treatment with IL-6 prompted PLum-AD cells to undergo EMT thus demonstrating a mesenchymal morphology (migratory phenotype with minimal cell-cell interactions). On the contrary, treatment with SB203580 had the opposite effect on PLum-AI cells that reverted to an epithelial morphology (cobble-stone appearing cells with well-defined cell-cell interactions) (Fig 3A). This evidence concerns the gene IL6 and Alzheimer disease.