Among the infection-specific ISGs upregulated during ΔHA-Cre infection are genes associated with apoptosis (Ripk2, Casp1, Ifi27, Pmaip1) and E3 ubiquitin ligases and proteasome genes, some of which are known to be involved in MHC-I antigen processing (Neurl3, Rnf19b, Psmb9). The gene discussed is PMAIP1; the disease is infection.