[26] Those guidelines also state that the plasma BNP concentrations in the second tertile (median: 52 pg/mL, interquartile: 42–65 pg/mL) indicate asymptomatic heart disease such as left ventricular hypertrophy, asymptomatic valvular heart disease, or ischemic heart disease, while the plasma BNP concentrations in the third tertile (median: 138 pg/mL, interquartile: 93–209 pg/mL) indicate latent heart failure. This evidence concerns the gene NPPB and heart valve disorder.