Among patients who achieved an SVR, a univariate analysis showed that patients who developed HCC were more frequently male and had liver cirrhosis, a history of HCC therapy, and lower platelet and albumin values and higher ALT, GGT, hyaluronic acid, fib-4 index, and AFP values before and at the end of treatment (Table 2). This evidence concerns the gene ALB and hepatocellular carcinoma.