Because the patients who underwent CT or MRI more frequently had liver cirrhosis and a history of HCC therapy, had higher total bilirubin, GGT, hyaluronic acid, Fib-4 index, and AFP values before therapy and at the end of treatment, and had lower platelet counts and albumin levels than those who underwent US alone (S1 Table). The gene discussed is AFP; the disease is hepatocellular carcinoma.