However, several circulating analytes including IFN-gamma, IL-10, IL-6, IL-15, sCD40L, IL-1RA, MCP-1, and IL-18 were modestly changed over the course of infection but then returned to baseline shortly after the acute phase of disease (approximately day 5–7), indicative of a controlled response to infection (Figs 2 and 3). This evidence concerns the gene IL18 and infection.