RBM20 cardiomyopathy also presents in a more severe fashion in male patients: In a patient collective of 80 RBM20 mutation carriers, men were both younger at diagnosis and presented with lower ejection fraction (“age, 29 ± 11 versus 48 ± 12 years; P < 0.01; ejection fraction, 29 ± 13% versus 38 ± 9%; P < 0.01”) [17•]. This evidence concerns the gene RBM20 and cardiomyopathy.