CaMKIIδ9 promotes cardiomyopathy and cell death by phosphorylation of ubiquitin-conjugating enzyme E2T (UBE2T), an enzyme in the Fanconi anemia DNA repair pathway, which leads to degradation of UBE2T and thereby accumulation of DNA damage [72•]. The gene discussed is UBE2T; the disease is Fanconi anemia.