To determine if naturally occurring mutations in SIRT6 in melanoma patients can inactivate the NER pathway, thereby promoting tumorigenesis, we identified nine melanoma patient-derived SIRT6 somatic mutations from COSMIC, variations called from whole-exome sequencing of TCGA samples and variations called from whole-genome sequencing of ICGC samples (Figure 7A, B). The gene discussed is SIRT6; the disease is melanoma.