There is an intriguing link to changes in expression of COL8A1 following skin remodeling after microneedling, which also leads to changes in expression of tissue inhibitor of metalloproteinases (TIMP)3, a gene in which mutations are causal for Sorsby's fundus dystrophy, a phenocopy of AMD.20 Possibly, there is a ECM–protein/matrix metalloproteinase/TIMP network. The gene discussed is TIMP1; the disease is Sorsby's fundus dystrophy.