There is an intriguing link to changes in expression of COL8A1 following skin remodeling after microneedling, which also leads to changes in expression of tissue inhibitor of metalloproteinases (TIMP)3, a gene in which mutations are causal for Sorsby's fundus dystrophy, a phenocopy of AMD.20 Possibly, there is a ECM–protein/matrix metalloproteinase/TIMP network. This evidence concerns the gene TIMP3 and age-related macular degeneration.