RNPC3 and Granuloma: The CRISPR-Cas9 treatment of eggs by electroporation in the presence of the RNP complex, or egg transduction with lentivirus particles expressing Cas9 and the gRNA, induced a detectable knock-down both at the mRNA and protein levels and a clear phenotype of smaller granulomas in mice exposed to CRISPR-Cas9-treated eggs.