BNIP2 and cancer: We found that the expression level of BNIP-2 is significantly reduced in breast tumor samples compared to normal tissues by analyzing two sets of breast carcinoma microarray data (GDS3853 and GDS3139; Fig. 3, A and B) and data from the TCGA (The Cancer Genome Atlas)–BRCA (Breast Invasive Carcinoma) database (fig.