SOD1 and amyotrophic lateral sclerosis: Of these, 83 cases had familial ALS, where 41 individuals (21 families) carry a SOD1 [NM_000454.4] p.I114T (c.341T>C) mutation, 33 individuals (two families) carry SOD1 p.V149G (c.446T>G), and nine individuals (two families) carry SOD1 p.E101G (c.302A>G) (Table 1).