In this study, we performed an IBD analysis leveraging WGS data to investigate founder events in a cohort of 83 Australian familial ALS cases from 25 families and three sporadic ALS cases with the most common SOD1 mutations in Australia: SOD1 p.I114T (c.341T>C), p.V149G (c.446T>G), p.E101G (c.302A>G)22. Here, SOD1 is linked to amyotrophic lateral sclerosis.