Patients in critically ill group were more likely to have lymphocytopenia (85.71% vs 68.75% vs 34.04%, p=0.002) and eosinoponia (31.91% vs 75.00% vs 83.33%, p=0.002), and were more likely to have higher IL-2R (71.43% vs 11.11% vs 6.90%, p<0.001), IL-6 (83.33% vs 27.78% vs 17.24%, p=0.005), IL-8 (57.14% vs 5.56% vs 3.45%, p<0.001), IL-10 (33.33% vs 5.56% vs 3.70%, p=0.046), TNF-α (71.43% vs 35.29% vs 0, p=0.008), LDH (100% vs 75.00% vs 36.96%, p<0.001) and cTnI (42.86% vs 9.52% vs 6.45%, p=0.025). This evidence concerns the gene TNF and lymphopenia.