To elucidate what influenced the progression of the disease exacerbation, we made a one-way analysis of variance and discovered that gender, age, disease severity, underlying diseases and several laboratory parameters (AST, LDH, IL-6, IL-2R, IL-8, D-dimer and cTnI) affected COVID-19 progress statically significantly (Table 6). This evidence concerns the gene IL6 and COVID-19.