POU5F1 and cancer: At present, OCT4, SOX2, C-Myc and KLF4 are considered as the core transcription factors that maintain the self-renewal capacity, and highly expressed in a variety of cancers, such as bladder cancer, prostate cancer, chronic myeloid leukemia, glioma, orthotopic colon cancer, lung adenocarcinoma, and pancreatic cancer 9-11.