POU5F1 and cancer: Overall, we may conclude that the invasiveness, tumorigenicity, drug resistance migration and angiogenesis capability of gastric cancer cell is significantly higher than cancer cell, as well as the expression of several markers, thus promising a new target for managing gastric cancer, we could study some targeted molecular drugs targeting to marker gene such as CD44, OCT4, SOX2 and Klf4, and we could also dedicate to study some drugs to inhibit cancer angiogenesis to eliminate the gastric cancer.