The result showed that the decreased expression of MYH9 had no effect on the proliferation of KYSE140 and KYSE180 (Figure 4C), but the cell migration and invasion activity were significantly inhibited (Figure 5), suggesting that MYH9 may be a critical oncogene of tumor metastasis of ESCC. The gene discussed is MYH9; the disease is esophageal squamous cell carcinoma.