HGF and cancer: Next step, the public cancer database (TCGA and GEO) were utilized to analyze the HGF and c-MET mRNA expression in peritumor and tumor tissues of gastric cancer patients, and the HGF and MET were both high-expressed in tumor tissues rather than those in peritumor ones (HGF: TCGA: P <0.01 and GSE27342: P <0.001; MET: TCGA: P <0.0001 and GSE27342: P <0.001; Figure 1B-E).