Our prior studies had found multiple genes and signaling pathways participated or play dominant role in tumorigenic process of gastric cancer, such as HGF, which secreted by cancer-associated fibroblasts, could promote vascularization in gastric cancer via activating PI3K/Akt and ERK1/2 signaling pathway 2, and accelerated proliferation, migration and invasion of MET-unamplified gastric cancer cells through activating c-MET/Stat3/twist1 signaling pathway 3. This evidence concerns the gene AKT1 and cancer.