Previous study have reported that high HGF level in pre-operative serum represent the invasive growth of tumor foci and c-MET positive immunostaining in gastric cancer tissues indicate the tumor with larger diameter, advanced lymphatic vessel invasion and lymph node metastasis 24, the above conclusion was supported by the outcome of our previous work and our colleagues, both of which shown HGF enhance tumorigenesis of gastric cancer via a paracrine pattern 2, 3, 25. This evidence concerns the gene HGF and gastric cancer.