We found that HGF-c-MET are enriched in MAPK signaling pathway, PI3K-Akt signaling pathway, JAK-Stat3 signaling pathway and biological process of positive regulation of cell migration, and these analyses had been validated in our prior study, which found PI3K/Akt and ERK1/2 signaling pathway participated in the process of HGF-dependent vascularization in gastric cancer and Jak2/Stat3 signaling pathway involved in the process of HGF-dependent migrant and invasive promotion of gastric cancer. The gene discussed is MAPK3; the disease is gastric cancer.