Besides, the methylation level and mRNA expression of HGF and c-MET in TCGA gastric cancer database were analyzed by the MethHC web tool, and results demonstrated that hypermethylation of promoter could decrease the c-MET mRNA expression with exception of HGF (c-MET: R=-0.175, P =0.0063; HGF: R=-0.014, P >0.05; Figure 3C&D). Here, HGF is linked to gastric cancer.