It was previously described, that transplantation of adipose tissue-derived stem cells, modified muscle progenitor cells or neural progenitor cells in ALS mice provides neuroprotective effects by production of trophic factors (such as: BDNF, NGF, IGF-1 and VEGF) what delays disease progression, and prolongs the life span of ALS mice 38-40. Here, BDNF is linked to amyotrophic lateral sclerosis.