RDH5 and hepatocellular carcinoma: To further determine whether the downregulation of RDH5 is associated with poor prognosis in HCC patients, 307 HCC specimens were analyzed for clinicopathological features: 63% (193 of 306) of HCC patients had low RDH5 expression, and the remaining 37% (113 of 306) had high RDH5 expression.