Univariate and multivariate Cox regression analysis of DEIRGs facilitated the construction of a seven-IRG prognostic model (GLP2R, INHBA CXCL1, STC2, SLC10A2, TDGF1, and ESM1), which could be reliably used for prognostic prediction in COAD patients. This evidence concerns the gene STC2 and colon adenocarcinoma.