ESM1 and colon adenocarcinoma: Multivariate Cox regression analysis revealed seven types of IRGs, including four types of high-risk IRGs (SLC10A2, STC2, ESM1 and INHBA) and three low-risk IRGs (CXCL1, TDGF1 and GLP2R), can be used to construct prognostic model of COAD, which also showed favorable feasibility for the result that AUC being 0.715.