Univariate and multivariate Cox regression analysis of DEIRGs facilitated the construction of a seven-IRG prognostic model (GLP2R, INHBA CXCL1, STC2, SLC10A2, TDGF1, and ESM1), which could be reliably used for prognostic prediction in COAD patients. The gene discussed is ESM1; the disease is colon adenocarcinoma.