Moreover, it was apparent from Figure 3E that the nine KEGG pathways sorted by the number of enriched DEIRGs were in order as follows: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Rheumatoid arthritis, IL-17 signaling pathway, cAMP signaling pathway, Amoebiasis, Natural killer (NK) cell mediated cytotoxicity, Salmonella infection and Renin-angiotensin system (RAS). This evidence concerns the gene REN and amebiasis.