Multivariate Cox regression analysis revealed seven types of IRGs, including four types of high-risk IRGs (SLC10A2, STC2, ESM1 and INHBA) and three low-risk IRGs (CXCL1, TDGF1 and GLP2R), can be used to construct prognostic model of COAD, which also showed favorable feasibility for the result that AUC being 0.715. Here, CXCL1 is linked to colon adenocarcinoma.