By analyzing signaling pathways as well as functional enrichment on DEIRGs, the nine KEGG pathways enriched DEIRGs were shown as follows: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Rheumatoid arthritis, IL-17 signaling pathway, cAMP signaling pathway, Amoebiasis, NK cell mediated cytotoxicity, Salmonella infection and RAS. Here, IL17A is linked to amebiasis.