Among the total 179 patients with stage I lung adenocarcinoma after complete surgical resection, patients with higher ASP scores tended to have poorly differentiation (p<0.001), vascular or lymphatic invasion (p<0.001) and abnormally elevated Ki67 expression (p<0.001), factors that are closely associated with a poor prognosis. This evidence concerns the gene MKI67 and lung adenocarcinoma.