HFE and Tangier disease: Complications of iron overload adults with Human homeostatic iron regulator protein (HFE)-associated hereditary hemochromatosis: involvement of heart (dilated cardiomyopathy and pericarditis), liver(chronic hepatitis, fibrosis, and cirrhosis) and endocrine glands( diabetes mellitus, hypoparathyroidism, hypothyroidism, hypopituitarism and low adrenal secretion).6 For the complication of iron overload serum ferritin has to be investigated along with endocrine function, cardiac function.6 Regular blood monitoring for the above condition that may appear has been performing in our patient too.