Among which, miR-141 was observed to inhibit the tumor suppressive function of SIK1 and promote ovarian cancer cell proliferation.137 Similarly, miR17 attenuated SIK1 levels, leading to promoting colorectal cancer proliferation and migration.140 MiR-203138 and miR-373141 promoted pancreatic cancer and melanoma cell proliferation, migration, and invasion by degrading SIK1. This evidence concerns the gene SIK1 and familial pancreatic carcinoma.