SIK1 and non-small cell lung carcinoma: As such, SIK1 and SIK3 have been revealed as the predominant downstream targets of LKB1 in mediating anti-tumorigenesis effect in NSCLC.42,43 While some studies provided that SIK2 underwent autophosphorylation and activation in vitro independent on the presence of LKB1.7 Therefore, whether other members of AMPK subfamily mediating LBK1 functions in metabolic homeostasis and tumorigenesis need more investigations, especially in combination with their conditional KO mouse models.