SIK1 and lung cancer: LncRNA ENST01108 served as a sponge to negatively regulate miR-489 levels, which negatively regulated SIK1, as a result, ENST01108 can promote glioma tumorigenesis.142 Analogously, lncRNA NR2F1-AS1 regulated the miR-17/SIK1 axis and inhibited the invasion and migration capability of cervical squamous cell carcinoma.143 In contrast, lncRNA TCONS_00029157, also termed SIK1-LNC, was positively associated with SIK1 expression, and they together inhibited lung cancer cell malignant phenotypes.144