DYNC1H1 and Neurodevelopmental delay: We propose a novel clinical classification of DYNC1H1-related disease entities that follows a holistic approach, focusing on the patients’ individual but complex clinical traits in the center of the classification, rather than the current reductionistic classification (e.g., SMALED or MRD13): DYNC1H1-related disorders with an exclusive NMD phenotype, DYNC1H1–NMD, and a combined NMD–CNS phenotype, DYNC1H1–NDD, on either sides of the spectrum (Fig. 4).