2 IU (i.e. 20 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upmu $$\end{document}μl of insulin solution) were administered for five consecutive injection, reaching a total 10 IU dosage (i.e. 100 μl of solution) in each individual experiment; this experimental setup was chosen to closely reproduce insulin injection technique and doses commonly used in diabetes care. This evidence concerns the gene INS and diabetes mellitus.