But TRACP-5b (r =  − 0.352, P < 0.05), PRL (r =  − 0.519, P < 0.01), duration of illness (r =  − 0.353, P < 0.05) were negatively correlated with BMD in male schizophrenia with elevated PRL levels. The gene discussed is PRL; the disease is schizophrenia.