Then a subnetwork (MCODE score:9.0) with ten nodes and 45 edges was selected, which revealed the critical roles of the ten genes (PTGER3, ADCY2, APLN, CXCL5, GRM4, MCHR1, NPY5R, CXCR4, ACKR3, MTNR1B) in clear cell renal cell carcinoma (Fig. 7b). Here, NPY5R is linked to clear cell renal carcinoma.