Then a subnetwork (MCODE score:9.0) with ten nodes and 45 edges was selected, which revealed the critical roles of the ten genes (PTGER3, ADCY2, APLN, CXCL5, GRM4, MCHR1, NPY5R, CXCR4, ACKR3, MTNR1B) in clear cell renal cell carcinoma (Fig. 7b). This evidence concerns the gene MTNR1B and clear cell renal carcinoma.