Remarkably, haplotype HLA-DQB1*06:01-DRB1*08:03 had a tendency to be more frequent in the patients with more severe PER-PAEs; four of 6 patients (66.7%) who showed self-injurious behavior or psychosis concomitantly had the DQB1*06:01 and DRB1*08:03 alleles (Table 2). This evidence concerns the gene HLA-DRB1 and psychotic disorder.