In an in vitro study on pancreatic ductal adenocarcinoma, Ma et al.39 reported that signal recognition particle receptor subunit beta (SRPRB) plays a central role in the interaction between proteins and stress-associated endoplasmic reticulum (ER) protein 1 (SERP1), which is responsible for the accumulation of unfolded protein in ER stress. Here, SRPRB is linked to pancreatic ductal adenocarcinoma.