Thus, men-specific immune characteristics interacting with/related to inflammaging, such as a blunted acquired immune system and type I interferon response, coupled with the downregulation of ACE2 (SARS-CoV-2 receptor) (particularly in patients with age-related comorbid diseases such as type II diabetes) and an accelerated biological aging (measured by epigenetic markers and telomere shortening), could help in explaining the higher vulnerability of men to COVID-19 infection [32]. Here, ACE2 is linked to type 2 diabetes mellitus.