SNCA and Parkinson disease: The normal distribution and functioning of aSyn-GFP in Snca-GFP mice led us to examine its utility for investigating the pathobiology of aSyn, specifically its formation into amyloid fibrils that accumulate within intracellular Lewy pathology found in PD and DLB (Arima et al., 1998; Takahashi and Wakabayashi, 2001).