Mutations in bona fide subunits of MICOS, MIC60, MIC13, and MIC26 are found in human diseases such as Parkinson’s (Tsai et al, 2018), mitochondrial encephalopathy with liver dysfunction (Guarani et al, 2016; Zeharia et al, 2016) and mitochondrial myopathy with lactic acidosis, cognitive impairment, and autistic features (Beninca et al, 2020), respectively. The gene discussed is APOO; the disease is Mitochondrial myopathy.