Further experiments are needed to provide mechanistic insights about how MIC26 and MIC27 affect OXPHOS complex biogenesis and cardiolipin levels and how this is linked to the pathophysiological role of these proteins in human diseases such as diabetic cardiomyopathy and mitochondrial myopathy (Beninca et al, 2020). The gene discussed is APOO; the disease is diabetic cardiomyopathy.