BMI-135 is a raloxifene derivative (Fig. 1) (Xiong et al., 2016) and was tested to determine whether the ShERPA BMI-135:ER:coregulators complex is an agonist in the human endometrial cancer cell line Ishikawa transfected with 5x-ERE (Fig. 4). This evidence concerns the gene ESR1 and endometrial cancer.