For example, IL-10 positive M2(IL-10)-like macrophages have been found in the lining layer of the synovium in rheumatoid arthritis (RA) and, more prominently, in spondylarthritis (SpA), whilst the sub-lining layers consisted more of a heterogenous M1/M2-like pattern [14]. The gene discussed is IL10; the disease is rheumatoid arthritis.