In addition, using specific shRNA, anti-IL-8 antibody, or reparixin, Al-Khalaf et al. found that the IL-8 signaling inhibition suppressed the active features of CAAs features, including non-cell-autonomous tumor-promoting activities both on breast luminal cells and in orthotopic tumor xenografts in mice [58]. The gene discussed is CXCL8; the disease is neoplasm.