Li et al. investigated that leptin triggered macrophage-related cytokine IL-18 production via NF-κB/NF-κB1 signaling in tumor-associated macrophages (TAMs), while via PI3K-AKT/ATF-2 signaling in BC cells, possibly contributing to BC invasion and metastasis [26]. The gene discussed is NFKB1; the disease is neoplasm.