A recent study showed that various CGG expansions of an FMR1 allele may lead to changes in RNA level and ratios of distinct RNA isoforms, which could regulate the translation and/or cellular localization of fragile X mental retardation protein (FMRP), affecting the expression of steroidogenic enzymes and hormonal receptors, that result in ovarian dysfunction [50]. The gene discussed is FMR1; the disease is ovarian dysfunction.