AHR and pulmonary arterial hypertension: On the other hand, iNECs induced robust CYP1 activity in pSAECs whose activity maxima were lower than Beas-2B cells, suggesting either the PAH threshold to induce metabolic induction in pSAECs was exceeded by iNECs or iNECs may cause metabolic induction independently of PAH-associated nuclear receptors, such as AhR.