The TNF-α was still high in OSA when the individuals were divided into groups from three continents (P < 0.0001): Asia: SMD 2.34, 95%CI: 1.67 to 3.01; Europe: SMD 1.44, 95%CI: 0.88 to 2.01; America: SMD 2.15, 95%CI: 0.60 to 3.70 (Fig. S3). The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.