EDN1 and breast cancer: Notwithstanding the previous finding, while pT1 and pT2/3 stage patients demonstrated signs of cardiac remodeling evidenced by the significantly increased indexed LV mass (Fig. 5a), big ET-1 levels significantly increased and correlated positively with indexed LV mass in pT2/3 but not pT1 stage patients (Fig. 5b, c, d) suggesting that the activation of ET-1 signaling is more pronounced in advanced stages of breast cancer.