The results of the multivariable logistic regression model showed that S1P (OR = 0.381, 95% CI = 0.171–0.848, p = 0.018), blood leukocyte count (OR = 0.438, 95% CI = 0.207–0.925, p = 0.030), and serum albumin (OR = 0.732, 95% CI = 0.556–0.962, p = 0.025) were independent factors associated with episode of peritonitis in the PD study population. Here, ALB is linked to peritonitis.