The basement membrane glycan expressed by the LUM gene is another kind of SLRP, which can promote tumorigenesis by activating downstream FAK and MAPK pathways, but some studies have found that basement membrane proteins can also down‐regulate EGFR‐mediated Akt activity, leading to pancreatic ductal adenocarcinoma in vitro proliferation is reduced.50 This evidence concerns the gene AKT1 and pancreatic ductal adenocarcinoma.