CD274 and neoplasm: Besides, CAFs can induce monocytes in leukocytes to differentiate into M2‐like macrophages and activate lymphocytes, and then bind programmed death ligand 1 (PD‐L1) on the cell surface to its receptor PD‐1, and release anti‐T cell activation signals to suppress antitumor immunity and promote tumor progression,32, 33 Gok.34