Frigolet Frigolet ME ME Torres Torres N N Tovar Tovar AR AR The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity J Nutrit Biochem J Nutrit Biochem 2013 2013 24 24 12 12 2003 2003 2015 2015 24120291 24120291. The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.