Kalupahana Kalupahana NS NS Moustaid-Moussa Moustaid-Moussa W W The renin-angiotensin system: a link between obesity, inflammation and insulin resistance The renin-angiotensin system: a link between obesity, inflammation and insulin resistance Obesity Rev Obesity Rev 2012 2012 13 13 2 2 136 136 149 149. This evidence concerns the gene REN and obesity due to melanocortin 4 receptor deficiency.