The histopathological and immunohistochemical evaluations were veryclose to the presented case’s findings, including positive staining for S100, aspecific marker for neural-based cells; for neurofilament which shows axonalfilaments; and for epithelial membrane antigen (EMA) which shows the capsule.Conversely, neurofibromas are non-encapsulated lesions with no staining for EMA. The gene discussed is MUC1; the disease is plexiform neurofibroma.